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N7 Methylation Alters Hydrogen Bonding Patterns of Guanine in Duplex DNA

N7-Alkyl-2′-deoxyguanosines are major adducts in DNA that are generated by various alkylating mutagens and drugs. However, the effect of the N7-alkylation on the hydrogen bonding patterns of the guanine remains poorly understood. We prepared N7-methyl-2′-deoxyguanosine (N7mdG)-containing DNA using a...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Kou, Yi, Koag, Myong-Chul, Lee, Seongmin
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704973/
https://ncbi.nlm.nih.gov/pubmed/26517568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b10172
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