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The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites

Crystal structures of the neurotransmitter:sodium symporter MhsT revealed occluded inward-facing states with one substrate (Trp) bound in the primary substrate (S1) site and a collapsed extracellular vestibule, which in LeuT contains the second substrate (S2) site. In n-dodecyl-β-d-maltoside, the de...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Quick, Matthias, Abramyan, Ara M., Wiriyasermkul, Pattama, Weinstein, Harel, Shi, Lei, Javitch, Jonathan A.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6112694/
https://ncbi.nlm.nih.gov/pubmed/30082383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717444115
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