Bone Morphogenetic Protein 9 Reduces Cardiac Fibrosis and Improves Cardiac Function in Heart Failure

BACKGROUND: Heart failure is a growing cause of morbidity and mortality worldwide. Transforming growth factor beta (TGF-β1) promotes cardiac fibrosis, but also activates counter-regulatory pathways that serve to regulate TGF-β1 activity in heart failure. Bone morphogenetic protein 9 (BMP9) is a memb...

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Udgivet i:Circulation
Main Authors: Morine, Kevin J., Qiao, Xiaoying, York, Sam, Natov, Peter S., Paruchuri, Vikram, Zhang, Yali, Aronovitz, Mark J., Karas, Richard H., Kapur, Navin K.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6111008/
https://ncbi.nlm.nih.gov/pubmed/29487140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.117.031635
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