Reduced Activin Receptor Like-Kinase 1 Activity Promotes Cardiac Fibrosis in Heart Failure

INTRODUCTION: Activin receptor-like kinase 1 (ALK1) mediates signaling via the transforming growth factor beta-1 (TGFβ1), a pro-fibrogenic cytokine. No studies have defined a role for ALK1 in heart failure. HYPOTHESIS: We tested the hypothesis that reduced ALK1 expression promotes maladaptive cardia...

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Detalhes bibliográficos
Publicado no:Cardiovasc Pathol
Main Authors: Morine, Kevin J., Qiao, Xiaoying, Paruchuri, Vikram, Aronovitz, Mark J., Mackey, Emily E., Buiten, Lyanne, Levine, Jonathan, Ughreja, Keshan, Nepali, Prerna, Blanton, Robert M., Oh, S. Paul, Karas, Richard H., Kapur, Navin K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5863230/
https://ncbi.nlm.nih.gov/pubmed/28820968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.carpath.2017.07.004
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