Reduced Activin Receptor Like-Kinase 1 Activity Promotes Cardiac Fibrosis in Heart Failure

INTRODUCTION: Activin receptor-like kinase 1 (ALK1) mediates signaling via the transforming growth factor beta-1 (TGFβ1), a pro-fibrogenic cytokine. No studies have defined a role for ALK1 in heart failure. HYPOTHESIS: We tested the hypothesis that reduced ALK1 expression promotes maladaptive cardia...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cardiovasc Pathol
Prif Awduron: Morine, Kevin J., Qiao, Xiaoying, Paruchuri, Vikram, Aronovitz, Mark J., Mackey, Emily E., Buiten, Lyanne, Levine, Jonathan, Ughreja, Keshan, Nepali, Prerna, Blanton, Robert M., Oh, S. Paul, Karas, Richard H., Kapur, Navin K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5863230/
https://ncbi.nlm.nih.gov/pubmed/28820968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.carpath.2017.07.004
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg