SLC6A3 Polymorphism Predisposes to Dopamine Overdose in Parkinson's Disease

In Parkinson's disease (PD), cognitive functions mediated by brain regions innervated by ventral tegmental area (VTA) worsen with dopamine replacement therapy, whereas processes relying on regions innervated by the substantia nigra pars compacta (SNc) improve. The SLC6A3 gene encodes the dopami...

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Udgivet i:Front Neurol
Main Authors: Robertson, Brian D., Al Jaja, Abdullah S., MacDonald, Alex A., Hiebert, Nole M., Tamjeedi, Ruzbeh, Seergobin, Ken N., Schwarz, Ute I., Kim, Richard B., MacDonald, Penny A.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Neurology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110885/
https://ncbi.nlm.nih.gov/pubmed/30186226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2018.00693
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