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Ribitol restores functionally glycosylated α-dystroglycan and improves muscle function in dystrophic FKRP-mutant mice

O-mannosylated α-dystroglycan (α-DG) serves as receptors for cell–cell and cell–extracellular matrix adhesion and signaling. Hypoglycosylation of α-DG is involved in cancer progression and underlies dystroglycanopathy with aberrant neuronal development. Here we report that ribitol, a pentose alcohol...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Cataldi, Marcela P., Lu, Peijuan, Blaeser, Anthony, Lu, Qi Long
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110760/
https://ncbi.nlm.nih.gov/pubmed/30150693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05990-z
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