Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21

Glucagon, an essential regulator of glucose and lipid metabolism, also promotes weight loss, in part through potentiation of fibroblast growth factor 21 (FGF21) secretion. However, FGF21 is only a partial mediator of metabolic actions ensuing from glucagon receptor (GCGR) activation, prompting us to...

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Bibliographic Details
Published in:Diabetes
Main Authors: Kim, Teayoun, Nason, Shelly, Holleman, Cassie, Pepin, Mark, Wilson, Landon, Berryhill, Taylor F., Wende, Adam R., Steele, Chad, Young, Martin E., Barnes, Stephen, Drucker, Daniel J., Finan, Brian, DiMarchi, Richard, Perez-Tilve, Diego, Tschöp, Matthias, Habegger, Kirk M.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2018
Subjects:
Obesity Studies
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110317/
https://ncbi.nlm.nih.gov/pubmed/29925501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-1502
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