Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21

Glucagon, an essential regulator of glucose and lipid metabolism, also promotes weight loss, in part through potentiation of fibroblast growth factor 21 (FGF21) secretion. However, FGF21 is only a partial mediator of metabolic actions ensuing from glucagon receptor (GCGR) activation, prompting us to...

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Dettagli Bibliografici
Pubblicato in:Diabetes
Autori principali: Kim, Teayoun, Nason, Shelly, Holleman, Cassie, Pepin, Mark, Wilson, Landon, Berryhill, Taylor F., Wende, Adam R., Steele, Chad, Young, Martin E., Barnes, Stephen, Drucker, Daniel J., Finan, Brian, DiMarchi, Richard, Perez-Tilve, Diego, Tschöp, Matthias, Habegger, Kirk M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2018
Soggetti:
Obesity Studies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110317/
https://ncbi.nlm.nih.gov/pubmed/29925501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-1502
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