Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21

Glucagon, an essential regulator of glucose and lipid metabolism, also promotes weight loss, in part through potentiation of fibroblast growth factor 21 (FGF21) secretion. However, FGF21 is only a partial mediator of metabolic actions ensuing from glucagon receptor (GCGR) activation, prompting us to...

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Опубликовано в: :Diabetes
Главные авторы: Kim, Teayoun, Nason, Shelly, Holleman, Cassie, Pepin, Mark, Wilson, Landon, Berryhill, Taylor F., Wende, Adam R., Steele, Chad, Young, Martin E., Barnes, Stephen, Drucker, Daniel J., Finan, Brian, DiMarchi, Richard, Perez-Tilve, Diego, Tschöp, Matthias, Habegger, Kirk M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2018
Предметы:
Obesity Studies
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110317/
https://ncbi.nlm.nih.gov/pubmed/29925501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-1502
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