Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21

Glucagon, an essential regulator of glucose and lipid metabolism, also promotes weight loss, in part through potentiation of fibroblast growth factor 21 (FGF21) secretion. However, FGF21 is only a partial mediator of metabolic actions ensuing from glucagon receptor (GCGR) activation, prompting us to...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Kim, Teayoun, Nason, Shelly, Holleman, Cassie, Pepin, Mark, Wilson, Landon, Berryhill, Taylor F., Wende, Adam R., Steele, Chad, Young, Martin E., Barnes, Stephen, Drucker, Daniel J., Finan, Brian, DiMarchi, Richard, Perez-Tilve, Diego, Tschöp, Matthias, Habegger, Kirk M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2018
Assuntos:
Obesity Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110317/
https://ncbi.nlm.nih.gov/pubmed/29925501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-1502
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