Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes

Indoleamine 2,3 dioxygenase-1 (IDO1) is a powerful immunoregulatory enzyme that is deficient in patients with type 1 diabetes (T1D). In this study, we present the first systematic evaluation of IDO1 expression and localization in human pancreatic tissue. Although IDO1 was constitutively expressed in...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Anquetil, Florence, Mondanelli, Giada, Gonzalez, Nathaly, Rodriguez Calvo, Teresa, Zapardiel Gonzalo, Jose, Krogvold, Lars, Dahl-Jørgensen, Knut, Van den Eynde, Benoit, Orabona, Ciriana, Grohmann, Ursula, von Herrath, Matthias G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2018
Assuntos:
Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110313/
https://ncbi.nlm.nih.gov/pubmed/29945890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-1281
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