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Pyruvate dehydrogenase complex deficiency is linked to regulatory loop disorder in the αV138M variant of human pyruvate dehydrogenase

The pyruvate dehydrogenase multienzyme complex (PDHc) connects glycolysis to the tricarboxylic acid cycle by producing acetyl-CoA via the decarboxylation of pyruvate. Because of its pivotal role in glucose metabolism, this complex is closely regulated in mammals by reversible phosphorylation, the mo...

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Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Whitley, Matthew J., Arjunan, Palaniappa, Nemeria, Natalia S., Korotchkina, Lioubov G., Park, Yun-Hee, Patel, Mulchand S., Jordan, Frank, Furey, William
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2018
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109939/
https://ncbi.nlm.nih.gov/pubmed/29970614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003996
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