Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics

Microtubule-associated protein 2c (MAP2c) is a 49-kDa intrinsically disordered protein regulating the dynamics of microtubules in developing neurons. MAP2c differs from its sequence homologue Tau in the pattern and kinetics of phosphorylation by cAMP-dependent protein kinase (PKA). Moreover, the mec...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Melková, Kateřina, Zapletal, Vojtěch, Jansen, Séverine, Nomilner, Erik, Zachrdla, Milan, Hritz, Jozef, Nováček, Jiří, Zweckstetter, Markus, Jensen, Malene R., Blackledge, Martin, Žídek, Lukáš
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2018
Teme:
Molecular Biophysics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109934/
https://ncbi.nlm.nih.gov/pubmed/29925592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001769
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