Quantitative mapping of microtubule-associated protein 2c (MAP2c) phosphorylation and regulatory protein 14-3-3ζ-binding sites reveals key differences between MAP2c and its homolog Tau

Microtubule-associated protein 2c (MAP2c) is involved in neuronal development and is less characterized than its homolog Tau, which has various roles in neurodegeneration. Using NMR methods providing single-residue resolution and quantitative comparison, we investigated molecular interactions import...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Jansen, Séverine, Melková, Kateřina, Trošanová, Zuzana, Hanáková, Kateřina, Zachrdla, Milan, Nováček, Jiří, Župa, Erik, Zdráhal, Zbyněk, Hritz, Jozef, Žídek, Lukáš
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399119/
https://ncbi.nlm.nih.gov/pubmed/28258221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.771097
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