Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics

Microtubule-associated protein 2c (MAP2c) is a 49-kDa intrinsically disordered protein regulating the dynamics of microtubules in developing neurons. MAP2c differs from its sequence homologue Tau in the pattern and kinetics of phosphorylation by cAMP-dependent protein kinase (PKA). Moreover, the mec...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Melková, Kateřina, Zapletal, Vojtěch, Jansen, Séverine, Nomilner, Erik, Zachrdla, Milan, Hritz, Jozef, Nováček, Jiří, Zweckstetter, Markus, Jensen, Malene R., Blackledge, Martin, Žídek, Lukáš
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109934/
https://ncbi.nlm.nih.gov/pubmed/29925592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001769
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