Glycation affects fibril formation of Aβ peptides

Increasing evidence shows that β-amyloid (Aβ) peptides, which are associated with Alzheimer disease (AD), are heavily glycated in patients, suggesting a role of this irreversible nonenzymatic post-translational modification in pathology. Previous reports have shown that glycation increases the toxic...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Emendato, Alessandro, Milordini, Giulia, Zacco, Elsa, Sicorello, Alessandro, Dal Piaz, Fabrizio, Guerrini, Remo, Thorogate, Richard, Picone, Delia, Pastore, Annalisa
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109928/
https://ncbi.nlm.nih.gov/pubmed/29959224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002275
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