Glycation of human serum albumin impairs binding to the glucagon-like peptide-1 analogue liraglutide

The long-acting glucagon-like peptide-1 analogue liraglutide has proven efficiency in the management of type 2 diabetes and also has beneficial effects on cardiovascular diseases. Liraglutide's protracted action highly depends on its capacity to bind to albumin via its palmitic acid part. Howev...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Gajahi Soudahome, Angélique, Catan, Aurélie, Giraud, Pierre, Assouan Kouao, Sandrine, Guerin-Dubourg, Alexis, Debussche, Xavier, Le Moullec, Nathalie, Bourdon, Emmanuel, Bravo, Susana B., Paradela-Dobarro, Beatriz, Álvarez, Ezequiel, Meilhac, Olivier, Rondeau, Philippe, Couprie, Joël
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880132/
https://ncbi.nlm.nih.gov/pubmed/29414771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.815274
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