Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with non-diabetic nephropathy than strong APOL1-second gene interactions

African Americans carrying two apolipoprotein L1 gene (APOL1) renal risk variants have a high risk for nephropathy. However, only a minority develops end-stage renal disease (ESRD). Hence, modifying factors likely contribute to initiation of kidney disease such as endogenous (HIV infection) or exoge...

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Detalhes bibliográficos
Publicado no:Kidney Int
Main Authors: Langefeld, Carl D., Comeau, Mary E., Ng, Maggie C., Guan, Meijian, Dimitrov, Latchezar, Mudgal, Poorva, Spainhour, Mitzie H., Julian, Bruce A., Edberg, Jeffrey C., Crocker, Jennifer A., Divers, Jasmin, Hicks, Pamela J., Bowden, Donald W., Chan, Gary C., Ma, Lijun, Palmer, Nicholette D., Kimberly, Robert P., Freedman, Barry I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109415/
https://ncbi.nlm.nih.gov/pubmed/29885931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2018.03.017
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