Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with non-diabetic nephropathy than strong APOL1-second gene interactions

African Americans carrying two apolipoprotein L1 gene (APOL1) renal risk variants have a high risk for nephropathy. However, only a minority develops end-stage renal disease (ESRD). Hence, modifying factors likely contribute to initiation of kidney disease such as endogenous (HIV infection) or exoge...

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Publicat a:Kidney Int
Autors principals: Langefeld, Carl D., Comeau, Mary E., Ng, Maggie C., Guan, Meijian, Dimitrov, Latchezar, Mudgal, Poorva, Spainhour, Mitzie H., Julian, Bruce A., Edberg, Jeffrey C., Crocker, Jennifer A., Divers, Jasmin, Hicks, Pamela J., Bowden, Donald W., Chan, Gary C., Ma, Lijun, Palmer, Nicholette D., Kimberly, Robert P., Freedman, Barry I.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109415/
https://ncbi.nlm.nih.gov/pubmed/29885931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2018.03.017
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