Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with non-diabetic nephropathy than strong APOL1-second gene interactions

African Americans carrying two apolipoprotein L1 gene (APOL1) renal risk variants have a high risk for nephropathy. However, only a minority develops end-stage renal disease (ESRD). Hence, modifying factors likely contribute to initiation of kidney disease such as endogenous (HIV infection) or exoge...

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Publicado en:Kidney Int
Autores principales: Langefeld, Carl D., Comeau, Mary E., Ng, Maggie C., Guan, Meijian, Dimitrov, Latchezar, Mudgal, Poorva, Spainhour, Mitzie H., Julian, Bruce A., Edberg, Jeffrey C., Crocker, Jennifer A., Divers, Jasmin, Hicks, Pamela J., Bowden, Donald W., Chan, Gary C., Ma, Lijun, Palmer, Nicholette D., Kimberly, Robert P., Freedman, Barry I.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109415/
https://ncbi.nlm.nih.gov/pubmed/29885931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2018.03.017
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