Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi

The SNAREs Vti1a/1b are implicated in regulated secretion, but their role relative to canonical exocytic SNAREs remains elusive. Here, we show that synaptic vesicle and dense-core vesicle (DCV) secretion is indeed severely impaired in Vti1a/b-deficient neurons. The synaptic levels of proteins that m...

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Publicat a:Nat Commun
Autors principals: Emperador-Melero, Javier, Huson, Vincent, van Weering, Jan, Bollmann, Christian, Fischer von Mollard, Gabriele, Toonen, Ruud F., Verhage, Matthijs
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109172/
https://ncbi.nlm.nih.gov/pubmed/30143604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05699-z
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