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Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons

The SNARE proteins involved in the secretion of neuromodulators from dense core vesicles (DCVs) in mammalian neurons are still poorly characterized. Here we use tetanus neurotoxin (TeNT) light chain, which cleaves VAMP1, 2 and 3, to study DCV fusion in hippocampal neurons and compare the effects on...

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發表在:Sci Rep
Main Authors: Hoogstraaten, Rein I., van Keimpema, Linda, Toonen, Ruud F., Verhage, Matthijs
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7331729/
https://ncbi.nlm.nih.gov/pubmed/32616842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67988-2
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