Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B

Protein phosphorylation is a prevalent and ubiquitous mechanism of regulation. Kinases are popular drug targets, but identifying selective phosphatase inhibitors has been challenging. Here, we used surface plasmon resonance to design a method to enable target-based discovery of selective serine/thre...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Krzyzosiak, Agnieszka, Sigurdardottir, Anna, Luh, Laura, Carrara, Marta, Das, Indrajit, Schneider, Kim, Bertolotti, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6108835/
https://ncbi.nlm.nih.gov/pubmed/30057111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.06.030
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