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Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B
Protein phosphorylation is a prevalent and ubiquitous mechanism of regulation. Kinases are popular drug targets, but identifying selective phosphatase inhibitors has been challenging. Here, we used surface plasmon resonance to design a method to enable target-based discovery of selective serine/thre...
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| Pubblicato in: | Cell |
|---|---|
| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cell Press
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6108835/ https://ncbi.nlm.nih.gov/pubmed/30057111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.06.030 |
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