Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation

BACKGROUND: Abnormal calcium (Ca(2+)) release from the sarcoplasmic reticulum (SR) contributes to the pathogenesis of atrial fibrillation (AF). Increased phosphorylation of two proteins essential for normal SR-Ca(2+) cycling, the type-2 ryanodine receptor (RyR2) and phospholamban (PLN), enhances the...

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Pubblicato in:Circulation
Autori principali: Alsina, Katherina M., Hulsurkar, Mohit, Brandenburg, Sören, Kownatzki-Danger, Daniel, Lenz, Christof, Urlaub, Henning, Abu-Taha, Issam, Kamler, Markus, Chiang, David Y., Lahiri, Satadru K., Reynolds, Julia O., Quick, Ann P., Scott, Larry, Word, Tarah A., Gelves, Maria D., Heck, Albert J.R., Li, Na, Dobrev, Dobromir, Lehnart, Stephan E., Wehrens, Xander H.T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699925/
https://ncbi.nlm.nih.gov/pubmed/31185731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.039642
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