Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation

BACKGROUND: Abnormal calcium (Ca(2+)) release from the sarcoplasmic reticulum (SR) contributes to the pathogenesis of atrial fibrillation (AF). Increased phosphorylation of two proteins essential for normal SR-Ca(2+) cycling, the type-2 ryanodine receptor (RyR2) and phospholamban (PLN), enhances the...

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Publicado en:Circulation
Autores principales: Alsina, Katherina M., Hulsurkar, Mohit, Brandenburg, Sören, Kownatzki-Danger, Daniel, Lenz, Christof, Urlaub, Henning, Abu-Taha, Issam, Kamler, Markus, Chiang, David Y., Lahiri, Satadru K., Reynolds, Julia O., Quick, Ann P., Scott, Larry, Word, Tarah A., Gelves, Maria D., Heck, Albert J.R., Li, Na, Dobrev, Dobromir, Lehnart, Stephan E., Wehrens, Xander H.T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699925/
https://ncbi.nlm.nih.gov/pubmed/31185731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.039642
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