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Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors
The reversible phosphorylation of proteins controls most cellular functions. Protein kinases have been popular drug targets, unlike phosphatases, which remain a drug discovery challenge. Guanabenz and Sephin1 are selective inhibitors of the phosphatase regulatory subunit PPP1R15A (R15A) that prolong...
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| Udgivet i: | Nat Struct Mol Biol |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5591645/ https://ncbi.nlm.nih.gov/pubmed/28759048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3443 |
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