Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL

After treatment with chimeric antigen receptor (CAR) T cells, interleukin-15 (IL-15) elevation and CAR T-cell expansion are associated with non-Hodgkin lymphoma (NHL) outcomes. However, the association of preinfusion CAR product T-cell functionality with clinical outcomes has not been reported. A si...

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Udgivet i:Blood
Main Authors: Rossi, John, Paczkowski, Patrick, Shen, Yueh-Wei, Morse, Kevin, Flynn, Brianna, Kaiser, Alaina, Ng, Colin, Gallatin, Kyle, Cain, Tom, Fan, Rong, Mackay, Sean, Heath, James R., Rosenberg, Steven A., Kochenderfer, James N., Zhou, Jing, Bot, Adrian
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2018
Fag:
Immunobiology and Immunotherapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6107882/
https://ncbi.nlm.nih.gov/pubmed/29895668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-01-828343
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