In Vivo Deletion of β-Cell Drp1 Impairs Insulin Secretion Without Affecting Islet Oxygen Consumption

Mitochondria are dynamic organelles that undergo frequent fission and fusion events. Mitochondrial fission is required for ATP production, the tricarboxylic acid cycle, and processes beyond metabolism in a cell-type specific manner. Ex vivo and cell line studies have demonstrated that Drp1, a centra...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Hennings, Thomas G, Chopra, Deeksha G, DeLeon, Elizabeth R, VanDeusen, Halena R, Sesaki, Hiromi, Merrins, Matthew J, Ku, Gregory M
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6107751/
https://ncbi.nlm.nih.gov/pubmed/30052866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2018-00445
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