Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem

Pancreatic ductal adenocarcinoma is characterised by a dense desmoplastic stroma composed of stromal cells and extracellular matrix (ECM). This barrier severely impairs drug delivery and penetration. Activated pancreatic stellate cells (PSCs) play a key role in establishing this unique pathological...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Han, Xuexiang, Li, Yiye, Xu, Ying, Zhao, Xiao, Zhang, Yinlong, Yang, Xiao, Wang, Yongwei, Zhao, Ruifang, Anderson, Gregory J., Zhao, Yuliang, Nie, Guangjun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6107580/
https://ncbi.nlm.nih.gov/pubmed/30139933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05906-x
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