ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer

Abundant desmoplastic stroma is the hallmark for pancreatic ductal adenocarcinoma (PDAC), which not only aggravates the tumor growth but also prevents tumor penetration of chemotherapy, leading to treatment failure. There is an unmet clinical need to develop therapeutic solutions to the tumor penetr...

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Publicado en:Sci Adv
Autores principales: Kuninty, Praneeth R., Bansal, Ruchi, De Geus, Susanna W. L., Mardhian, Deby F., Schnittert, Jonas, van Baarlen, Joop, Storm, Gert, Bijlsma, Maarten F., van Laarhoven, Hanneke W., Metselaar, Josbert M., Kuppen, Peter J. K., Vahrmeijer, Alexander L., Östman, Arne, Sier, Cornelis F. M., Prakash, Jai
Formato: Artigo
Lenguaje:Inglês
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726450/
https://ncbi.nlm.nih.gov/pubmed/31517053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax2770
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