MicroRNA-199a and -214 as potential therapeutic targets in pancreatic stellate cells in pancreatic tumor

Pancreatic stellate cells (PSCs) are the key precursor cells for cancer-associated fibroblasts (CAFs) in pancreatic tumor stroma. In this study, we explored miRNA as therapeutic targets in tumor stroma and found miR-199a-3p and miR-214-3p induced in patient-derived pancreatic CAFs and TGF-β-activate...

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Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Kuninty, Praneeth R., Bojmar, Linda, Tjomsland, Vegard, Larsson, Marie, Storm, Gert, Östman, Arne, Sandström, Per, Prakash, Jai
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941323/
https://ncbi.nlm.nih.gov/pubmed/26918939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7651
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