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The catch bond mechanism between von Willebrand Factor and platelet surface receptors investigated by molecular dynamics simulations: Catch bond between VWF and platelets
The multi-domain protein von Willebrand Factor is crucial in the blood coagulation process at high shear. The A1 domain binds to the platelet surface receptor glycoprotein Ibα (GpIbα) and this interaction is known to be strengthened by tensile force. The molecular mechanism behind this observation w...
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| Publicado no: | Proteins |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6107302/ https://ncbi.nlm.nih.gov/pubmed/20602356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22759 |
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