Structural Basis of Type 2A von Willebrand Disease Investigated by Molecular Dynamics Simulations and Experiments

The hemostatic function of von Willebrand factor is downregulated by the metalloprotease ADAMTS13, which cleaves at a unique site normally buried in the A2 domain. Exposure of the proteolytic site is induced in the wild-type by shear stress as von Willebrand factor circulates in blood. Mutations in...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Interlandi, Gianluca, Ling, Minhua, Tu, An Yue, Chung, Dominic W., Thomas, Wendy E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479114/
https://ncbi.nlm.nih.gov/pubmed/23110044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045207
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky