Deletion of the ORF2 gene of the neuropathogenic equine herpesvirus type 1 strain Ab4 reduces virulence while maintaining strong immunogenicity

BACKGROUND: Equine herpesvirus type 1 (EHV-1) induces respiratory infection, abortion, and neurologic disease with significant impact. Virulence factors contributing to infection and immune evasion are of particular interest. A potential virulence factor of the neuropathogenic EHV-1 strain Ab4 is OR...

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Publicado en:BMC Vet Res
Autores principales: Schnabel, Christiane L., Wimer, Christine L., Perkins, Gillian, Babasyan, Susanna, Freer, Heather, Watts, Christina, Rollins, Alicia, Osterrieder, Nikolaus, Wagner, Bettina
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6106926/
https://ncbi.nlm.nih.gov/pubmed/30134896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12917-018-1563-4
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