A Point Mutation in a Herpesvirus Polymerase Determines Neuropathogenicity

Infection with equid herpesvirus type 1 (EHV-1) leads to respiratory disease, abortion, and neurologic disorders in horses. Molecular epidemiology studies have demonstrated that a single nucleotide polymorphism resulting in an amino acid variation of the EHV-1 DNA polymerase (N752/D752) is significa...

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Detalhes bibliográficos
Main Authors: Goodman, Laura B, Loregian, Arianna, Perkins, Gillian A, Nugent, Josie, Buckles, Elizabeth L, Mercorelli, Beatrice, Kydd, Julia H, Palù, Giorgio, Smith, Ken C, Osterrieder, Nikolaus, Davis-Poynter, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2065875/
https://ncbi.nlm.nih.gov/pubmed/17997600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.0030160
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