The deletion of the ORF1 and ORF71 genes reduces virulence of the neuropathogenic EHV-1 strain Ab4 without compromising host immunity in horses

The equine herpesvirus type 1 (EHV-1) ORF1 and ORF71 genes have immune modulatory effects in vitro. Experimental infection of horses using virus mutants with multiple deletions including ORF1 and ORF71 showed promise as vaccine candidates against EHV-1. Here, the combined effects of ORF1 and ORF71 d...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Wimer, Christine L., Schnabel, Christiane L., Perkins, Gillian, Babasyan, Susanna, Freer, Heather, Stout, Alison E., Rollins, Alicia, Osterrieder, Nikolaus, Goodman, Laura B., Glaser, Amy, Wagner, Bettina
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2018
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237298/
https://ncbi.nlm.nih.gov/pubmed/30440016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206679
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