PDE4 and mAKAPβ are nodal organizers of β(2)-ARs nuclear PKA signalling in cardiac myocytes

AIMS: β(1)- and β(2)-adrenergic receptors (β-ARs) produce different acute contractile effects on the heart partly because they impact on different cytosolic pools of cAMP-dependent protein kinase (PKA). They also exert different effects on gene expression but the underlying mechanisms remain unknown...

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Publicado en:Cardiovasc Res
Autores principales: Bedioune, Ibrahim, Lefebvre, Florence, Lechêne, Patrick, Varin, Audrey, Domergue, Valérie, Kapiloff, Michael S, Fischmeister, Rodolphe, Vandecasteele, Grégoire
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6106106/
https://ncbi.nlm.nih.gov/pubmed/29733383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvy110
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