Delineating the Physiological Roles of the PE and Catalytic Domains of LipY in Lipid Consumption in Mycobacterium-Infected Foamy Macrophages

Within tuberculous granulomas, a subpopulation of Mycobacterium tuberculosis resides inside foamy macrophages (FM) that contain abundant cytoplasmic lipid bodies (LB) filled with triacylglycerol (TAG). Upon fusion of LB with M. tuberculosis-containing phagosomes, TAG is hydrolyzed and reprocessed by...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Santucci, Pierre, Diomandé, Sadia, Poncin, Isabelle, Alibaud, Laetitia, Viljoen, Albertus, Kremer, Laurent, de Chastellier, Chantal, Canaan, Stéphane
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105901/
https://ncbi.nlm.nih.gov/pubmed/29986895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00394-18
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