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In Vivo Efficacy of Plazomicin Alone or in Combination with Meropenem or Tigecycline against Enterobacteriaceae Isolates Exhibiting Various Resistance Mechanisms in an Immunocompetent Murine Septicemia Model

Plazomicin is a novel aminoglycoside with potent in vitro activity against multidrug- and carbapenem-resistant Enterobacteriaceae. The objective of this study was to assess the efficacy of plazomicin exposure, alone and in combination with meropenem or tigecycline, against Enterobacteriaceae in the...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Abdelraouf, Kamilia, Kim, Aryun, Krause, Kevin M., Nicolau, David P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105799/
https://ncbi.nlm.nih.gov/pubmed/29866866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01074-18
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