Assessment of the In Vivo Efficacy of Plazomicin (PLZ) Alone or in Combination with Meropenem (MEM) or Tigecycline (TGC) against Enterobacteriaceae (EB) Isolates Exhibiting Various Resistance Mechanisms in an Immunocompetent (I+) Murine Septicemia Model

BACKGROUND: PLZ is a next-generation aminoglycoside with potent in vitro activity against multidrug- and carbapenem-resistant EB. The objective of this study was to assess the efficacy of PLZ human-simulated exposure, alone and in combination with MEM or TGC, against EB in the I+ murine septicemia m...

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Vydáno v:Open Forum Infect Dis
Hlavní autoři: Abdelraouf, Kamilia, Kim, Aryun, Krause, Kevin M, Nicolau, David P
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5631146/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofx163.1202
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