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HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
It is definitively established that mutations in transcription factor HIF-2α are causative of both neuroendocrine tumors (class 1 disease) and polycythemia (class 2 disease). However, the molecular mechanism that underlies this emergent genotype–phenotype relationship has remained unclear. Here, we...
Enregistré dans:
| Publié dans: | Nat Commun |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6105673/ https://ncbi.nlm.nih.gov/pubmed/30135421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05554-1 |
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