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Astrocyte-specific overexpression of Nrf2 protects against optic tract damage and behavioural alterations in a mouse model of cerebral hypoperfusion

Mouse models have shown that cerebral hypoperfusion causes white matter disruption and memory impairment relevant to the study of vascular cognitive impairment and dementia. The associated mechanisms include inflammation and oxidative stress are proposed to drive disruption of myelinated axons withi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sigfridsson, Emma, Marangoni, Martina, Johnson, Jeffrey A., Hardingham, Giles E., Fowler, Jill H., Horsburgh, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105641/
https://ncbi.nlm.nih.gov/pubmed/30135571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30675-4
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