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Tacrolimus Population Pharmacokinetics and Multiple CYP3A5 Genotypes in African American and White Renal Transplant Recipients
Tacrolimus exhibits inter-patient pharmacokinetic variability attributed to CYP3A5 isoenzymes and the efflux transporter, P-glycoprotein. Most African American renal transplant recipients require higher tacrolimus doses compared to whites to achieve similar troughs when race-adjusted recommendations...
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| Publicado no: | J Clin Pharmacol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6105387/ https://ncbi.nlm.nih.gov/pubmed/29775201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1118 |
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