Tacrolimus Population Pharmacokinetics and Multiple CYP3A5 Genotypes in African American and White Renal Transplant Recipients

Tacrolimus exhibits inter-patient pharmacokinetic variability attributed to CYP3A5 isoenzymes and the efflux transporter, P-glycoprotein. Most African American renal transplant recipients require higher tacrolimus doses compared to whites to achieve similar troughs when race-adjusted recommendations...

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Publicado en:J Clin Pharmacol
Autores principales: Campagne, Olivia, Mager, Donald E., Brazeau, Daniel, Venuto, Rocco C., Tornatore, Kathleen M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105387/
https://ncbi.nlm.nih.gov/pubmed/29775201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1118
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