Beyond Single Nucleotide Polymorphisms: CYP3A5(∗)3(∗)6(∗)7 Composite and ABCB1 Haplotype Associations to Tacrolimus Pharmacokinetics in Black and White Renal Transplant Recipients

Interpatient variability in tacrolimus pharmacokinetics is attributed to metabolism by cytochrome P-450 3A5 (CYP3A5) isoenzymes and membrane transport by P-glycoprotein. Interpatient pharmacokinetic variability has been associated with genotypic variants for both CYP3A5 or ABCB1. Tacrolimus pharmaco...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Brazeau, Daniel A., Attwood, Kristopher, Meaney, Calvin J., Wilding, Gregory E., Consiglio, Joseph D., Chang, Shirley S., Gundroo, Aijaz, Venuto, Rocco C., Cooper, Louise, Tornatore, Kathleen M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7433713/
https://ncbi.nlm.nih.gov/pubmed/32849848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.00889
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