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A Spatially Explicit Model Shows How Titin Stiffness Modulates Muscle Mechanics and Energetics

In striated muscle, the giant protein titin spans the entire length of a half-sarcomere and extends from the backbone of the thick filament, reversibly attaches to the thin filaments, and anchors to the dense protein network of the z-disk capping the end of the half-sarcomere. However, little is kno...

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Detalhes bibliográficos
Publicado no:Integr Comp Biol
Main Authors: Powers, Joseph D, Williams, C David, Regnier, Michael, Daniel, Thomas L
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104699/
https://ncbi.nlm.nih.gov/pubmed/29897447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/icb/icy055
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