Discovery and Optimization of Potent and CNS Penetrant M(5)-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold

[Image: see text] The pharmacology of the M(5) muscarinic acetylcholine receptor (mAChR) is the least understood of the five mAChR subtypes due to a historic lack of selective small molecule tools. To address this shortcoming, we have continued the optimization effort around the prototypical M(5) po...

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Published in:ACS Chem Neurosci
Main Authors: Bender, Aaron M., Cho, Hyekyung P., Nance, Kellie D., Lingenfelter, Kaelyn S., Luscombe, Vincent B., Gentry, Patrick R., Voigtritter, Karl, Berizzi, Alice E., Sexton, Patrick M., Langmead, Christopher J., Christopoulos, Arthur, Locuson, Charles W., Bridges, Thomas M., Chang, Sichen, O’Neill, Jordan C., Zhan, Xiaoyan, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104635/
https://ncbi.nlm.nih.gov/pubmed/29678111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00126
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