Discovery and Optimization of Potent and CNS Penetrant M(5)-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold

[Image: see text] The pharmacology of the M(5) muscarinic acetylcholine receptor (mAChR) is the least understood of the five mAChR subtypes due to a historic lack of selective small molecule tools. To address this shortcoming, we have continued the optimization effort around the prototypical M(5) po...

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書誌詳細
出版年:ACS Chem Neurosci
主要な著者: Bender, Aaron M., Cho, Hyekyung P., Nance, Kellie D., Lingenfelter, Kaelyn S., Luscombe, Vincent B., Gentry, Patrick R., Voigtritter, Karl, Berizzi, Alice E., Sexton, Patrick M., Langmead, Christopher J., Christopoulos, Arthur, Locuson, Charles W., Bridges, Thomas M., Chang, Sichen, O’Neill, Jordan C., Zhan, Xiaoyan, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104635/
https://ncbi.nlm.nih.gov/pubmed/29678111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00126
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