Poly (ADP-Ribose) Polymerase 1 Mediated Arginase II Activation Is Responsible for Oxidized LDL-Induced Endothelial Dysfunction

It is well known that arginase II leads to decreased synthesis of nitric oxide (NO) by competing with endothelial nitric oxide synthase (eNOS) for their same substrate L-arginine. However, the regulatory mechanisms of arginase II production remain unclear. In this study, we hypothesized that poly- (...

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Vydáno v:Front Pharmacol
Hlavní autoři: Wang, Qi, Zhao, Tong, Zhang, Wei, Yu, Wenbin, Liu, Bin, Wang, Zhaoyang, Qiao, Wen, Lu, Qinghua, Wang, Aihua, Zhang, Mingxiang
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104189/
https://ncbi.nlm.nih.gov/pubmed/30158868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00882
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