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Binding kinetics of cariprazine and aripiprazole at the dopamine D(3) receptor
The dissociation behaviours of aripiprazole and cariprazine at the human D(2) and D(3) receptor are evaluated. A potential correlation between kinetics and in vivo profiles, especially cariprazine’s action on negative symptoms in schizophrenia, is investigated. The binding kinetics of four ligands w...
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| Gepubliceerd in: | Sci Rep |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group UK
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6104066/ https://ncbi.nlm.nih.gov/pubmed/30131592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30794-y |
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