Cariprazine exerts antimanic properties and interferes with dopamine D(2) receptor β-arrestin interactions

Activation of dopamine D(2) receptors (D(2)R) modulates G protein/cAMP-dependent signaling and also engages Akt-GSK-3 signaling through D(2)R/β-arrestin 2 scaffolding of Akt and PP2A. This G protein-independent pathway may be important in mediating the antimanic effects of mood stabilizers and antip...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Gao, Yonglin, Peterson, Sean, Masri, Bernard, Hougland, M Tyler, Adham, Nika, Gyertyán, Istvan, Kiss, Béla, Caron, Marc G, El-Mallakh, Rif S
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317219/
https://ncbi.nlm.nih.gov/pubmed/25692006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.73
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