Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity

RATIONALE: Aberrant glutamatergic, dopaminergic, and GABAergic neurotransmission has been implicated in schizophrenia. Cariprazine reverses the behavioral effects observed in the rat phencyclidine (PCP)-induced model of schizophrenia; however, little is known about its in vivo neurochemistry. OBJECT...

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Detalhes bibliográficos
Publicado no:Psychopharmacology (Berl)
Main Authors: Kehr, Jan, Yoshitake, Takashi, Ichinose, Fumio, Yoshitake, Shimako, Kiss, Béla, Gyertyán, István, Adham, Nika
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2018
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920013/
https://ncbi.nlm.nih.gov/pubmed/29637288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-018-4874-z
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