A FTIR microspectroscopy study of the structural and biochemical perturbations induced by natively folded and aggregated transthyretin in HL-1 cardiomyocytes

Protein misfolding and aggregation are associated with a number of human degenerative diseases. In spite of the enormous research efforts to develop effective strategies aimed at interfering with the pathogenic cascades induced by misfolded/aggregated peptides/proteins, the necessary detailed unders...

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Udgivet i:Sci Rep
Main Authors: Ami, Diletta, Mereghetti, Paolo, Leri, Manuela, Giorgetti, Sofia, Natalello, Antonino, Doglia, Silvia Maria, Stefani, Massimo, Bucciantini, Monica
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104026/
https://ncbi.nlm.nih.gov/pubmed/30131519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30995-5
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