Mitochondrial accumulation of doxorubicin in cardiac and diaphragm muscle following exercise preconditioning

Doxorubicin (DOX) is a highly effective anthracycline antibiotic. Unfortunately, the clinical use of DOX is limited by the risk of deleterious effects to cardiac and respiratory (i.e. diaphragm) muscle, resulting from mitochondrial reactive oxygen species (ROS) production. In this regard, exercise i...

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Bibliographic Details
Published in:Mitochondrion
Main Authors: Morton, Aaron B., Mor, Andres, Hinkley, J. Matthew, Ichinoseki-Sekine, Noriko, Christou, Demetra D., Smuder, Ashley J.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6103903/
https://ncbi.nlm.nih.gov/pubmed/29474837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2018.02.005
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