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Oxidative stress impairs autophagy through oxidation of ATG3 and ATG7

Dysfunctional macroautophagy/autophagy has been causatively linked to aging and the pathogenesis of many diseases, which are also broadly characterized by dysregulated cellular redox. As the autophagy-related (ATG) conjugation systems that mediate autophagosome maturation are cysteine dependent, the...

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Bibliografiske detaljer
Udgivet i:Autophagy
Hovedforfatter: Burgoyne, Joseph Robert
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6103406/
https://ncbi.nlm.nih.gov/pubmed/29746182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1444311
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